Prevalence of ZAP-70 and CD 38 in Indian chronic lymphocytic leukemia patients.
Indian J Cancer
;
2013 Oct-Dec; 50(4): 333-336
Article
in English
| IMSEAR
| ID: sea-154308
ABSTRACT
Aim of Study Chronic lymphocytic leukemia (CLL) is the most common chronic lympho-proliferative disorder. This study was undertaken to know the prevalence of ZAP-70 and CD 38 in the treatment naive patients of CLL seen at a tertiary care centre of north India. Materials and Methods:
ZAP-70 and CD 38 were tested by flow cytometry on peripheral blood samples. ZAP-70 positive and CD 38 positivity was defined as positive expression on 20% and 30% of CLL cells, respectively. Clinico-hematological profile and its correlation with ZAP-70 and CD 38 were assessed in consecutive 80 CLL patients.Results:
There were 64 males and median age of the group was 58 years. Sixteen patients (20%) were asymptomatic and diagnosed incidentally. Median total lymphocyte count (TLC) at presentation was 62 × 10 9 /L. Rai stage distribution was Stage 0-6, stage I-20, stage II-36, stage III-5, and stage IV-13. ZAP-70 and CD 38 positivity were detected in 20 patients (25%) and 29 patients (36%), respectively. Eleven patients were positive and 34 were negative for both ZAP-70 and CD 38 yielding a concordance rate of 56%. There was no statistically significant difference between ZAP-70 and CD 38 positivity and negativity with regard to age, sex, Lymphocyte count, lymphadenopathy, organomegaly, and Rai staging.Conclusion:
ZAP-70 and CD 38 positivity were detected 25% and 36%, respectively, with concordance rate of 56%, which is higher than Western literature. There was no correlation of ZAP-70 and CD 38 positivity with age, sex, lymphadenopathy, organomegaly, and Rai staging.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Aged, 80 and over
/
Aged
/
Female
/
Humans
/
Male
/
Leukemia, Lymphocytic, Chronic, B-Cell
/
Prevalence
/
Adult
/
ADP-ribosyl Cyclase 1
/
ZAP-70 Protein-Tyrosine Kinase
Type of study:
Prevalence study
/
Risk factors
Limits:
Aged80
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Cancer
Year:
2013
Type:
Article
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