Free oxygen radicals in acute renal failure.
Indian Pediatr
;
2000 Feb; 37(2): 153-8
Article
in English
| IMSEAR
| ID: sea-15446
ABSTRACT
OBJECTIVE:
To assess the levels of free oxygen radicals in acute renal failure and their predictive value in clinical outcome.DESIGN:
Prospective.SETTING:
Intensive care unit.METHODS:
Study was conducted in 50 children (25 with acute renal failure and 25 age and sex matched controls). Blood urea, serum creatinine, serum protein, uric acid and free oxygen radical markers were estimated in both groups. Superoxide dismutase (SOD), glutathione peroxidase(GPx) and lipid peroxide (LPO) were estimated in blood by standard techniques.RESULTS:
Hemolytic uremic syndrome (HUS) was a major cause of acute renal failure (52%), rest were due to acute glomerulonephritis (AGN), septicemia and renal venous thrombosis. In the renal failure group 56% of the patients were dialyzed (peritoneal) and the mortality was 28% (7/25). The levels of SOD, GPx and LPO were significantly raised in renal failure group. Higher values of LPO, SOD and GPx were documented in subjects who expired. The most important independent variable for predicting clinical outcome was LPO with a sensitivity of 89.4%, specificity of 93%, positive predictive value of 95%.CONCLUSION:
Levels of free oxygen radicals (SOD, LPO and GPx) are raised in acute renal failure and these enzymes can be used as marker of renal injury. LPO levels are highly sensitivity and specific for predicting the clinicaloutcome:
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Oxidoreductases
/
Female
/
Humans
/
Male
/
Biomarkers
/
Case-Control Studies
/
Child
/
Child, Preschool
/
Multivariate Analysis
/
Survival Rate
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Indian Pediatr
Year:
2000
Type:
Article
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