Randomized controlled study to evaluate the effectiveness of dexamethasone oral minipulse therapy versus oral minocycline in patients with active vitiligo vulgaris.
Indian J Dermatol Venereol Leprol
;
2014 Jan-Feb; 80(1): 29-35
Article
in English
| IMSEAR
| ID: sea-154740
ABSTRACT
Background:
Oral minocycline has been recently shown to halt disease progression in active vitiligo.Aims:
The present study was planned to compare the efficacy and tolerability of oral minocycline with oral mini pulse (OMP) corticosteroids in active vitiligo.Methods:
A total of 50 patients with actively spreading vitiligo were randomized to receive either minocycline 100 mg/day (Group I - 25 patients) or OMP 2.5 mg dexamethasone on 2 consecutive days in a week (Group II - 25 patients) for 6 months. These were followed-up at every 2 weeks interval. Mean vitiligo disease activity score (VIDA) and mean Vitiligo Area Scoring Index (VASI) were assessed in all patients in addition to the photographic comparison before and after treatment.Results:
Both groups showed a significant decrease in VIDA from 4.0 to 1.64 ± 0.86 (P < 0.001) in Group I and from 4.0 to 1.68 ± 0.69 (P < 0.001) in Group II. However, the difference between the mean VIDA scores in the two groups was not statistically significant (P = 0.60) at the end of treatment period. The mean VASI declined from 1.71 ± 1.45 to 1.52 ± 1.43 Group I (P = 0.06) and from 1.39 ± 1.31 to 1.17 ± 1.34 in Group II (P = 0.05). The difference between VASI in Group I and II was not significant at the end of 24 weeks of treatment (P = 0.11).Conclusion:
Both dexamethasone OMP and oral minocycline are effective drugs for managing the arrest of disease activity in vitiligo.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Vitiligo
/
Female
/
Humans
/
Male
/
Dexamethasone
/
Randomized Controlled Trials as Topic
/
Administration, Oral
/
Adolescent
/
Adult
/
Pulse Therapy, Drug
Type of study:
Controlled clinical trial
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2014
Type:
Article
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