Your browser doesn't support javascript.
loading
Tumor necrosis factor-α antagonists: Side effects and their management.
Indian J Dermatol Venereol Leprol ; 2013 Jul; 79(Suppl_7):s35-s46
Article in English | IMSEAR | ID: sea-154745
ABSTRACT
As elevated levels of tumor necrosis factor-alpha (TNF-α) are associated with disease severity in psoriasis and psoriatic arthritis, TNF-α antagonists are being used to treat moderate to severe disease in patients who have contraindications, fail to respond or develop side effects to conventional systemic therapies. It is of utmost importance to be well versed with the possible adverse effects and contraindications of TNF-α antagonists so that they can be used effectively and safely. Many of their adverse effects have been well studied in patients of rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) and may not be completely applicable in psoriasis. This is because patients with RA and IBD are on multiple immunosuppressants while those with psoriasis are mostly receiving single systemic therapy and often have comorbidities that distinguish them from those with RA or IBD. Also, some of the side effects are still controversial and debated. Long-term prospective randomized controlled studies are needed to better understand the associated risk in patients of psoriasis. Baseline screening and periodic monitoring during treatment can reduce and help in early identification and appropriate management of the adverse outcomes. This article reviews the side effects known to be associated with TNF-α antagonists, their pathomechanisms and management guidelines. Some of the common side effects include infusion and injection site reactions, infections particularly reactivation of tuberculosis, autoantibody formation and drug induced lupus erythematosus, liver function abnormalities, hematological, and solid organ malignancies.
Subject(s)

Full text: Available Index: IMSEAR (South-East Asia) Main subject: Psoriasis / Thrombocytopenia / Thromboembolism / Abnormalities, Drug-Induced / Humans / Immunoglobulin G / Anti-Inflammatory Agents, Non-Steroidal / Tumor Necrosis Factor-alpha / Receptors, Tumor Necrosis Factor / Drug Hypersensitivity Type of study: Controlled clinical trial / Practice guideline / Prognostic study Language: English Journal: Indian J Dermatol Venereol Leprol Year: 2013 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: IMSEAR (South-East Asia) Main subject: Psoriasis / Thrombocytopenia / Thromboembolism / Abnormalities, Drug-Induced / Humans / Immunoglobulin G / Anti-Inflammatory Agents, Non-Steroidal / Tumor Necrosis Factor-alpha / Receptors, Tumor Necrosis Factor / Drug Hypersensitivity Type of study: Controlled clinical trial / Practice guideline / Prognostic study Language: English Journal: Indian J Dermatol Venereol Leprol Year: 2013 Type: Article