Safety and effectiveness of autoinoculation therapy in cutaneous warts: A double - blind, randomized, placebo - controlled study.
Indian J Dermatol Venereol Leprol
;
2014 Nov-Dec; 80(6): 515-520
Article
in English
| IMSEAR
| ID: sea-154886
ABSTRACT
Background:
In spite of the availability of multiple treatment options, viral warts are known for their persistence and recurrence, causing frustration to patients and treating physicians.Aims:
To study the effectiveness and safety of autoinoculation as a treatment modality in cutaneous warts.Methods:
A double‑blind, placebo‑controlled study was carried out. In the treatment group, full‑thickness warty tissue was excised, minced and implanted in a small dermal pocket. In the control group, warty tissue was only excised and not implanted, though a dermal pocket was made. Patients were evaluated every four weeks with lesion counts. The procedure was repeated at 4 and 8 weeks. Response was assessed at each visit and at 12 weeks.Results:
Forty‑eight patients with cutaneous warts (male female = 3216) were randomized into autoinoculation and control groups. The number of warts at baseline was comparable in both groups (P = 0.293). Reduction in the number of warts was significantly more in the autoinoculation group (8.50 ± 13.88) than in the control group (10.04 ± 5.80) from 8 weeks onwards (P = 0.010). Complete resolution occurred only in the autoinoculation group, in 62.5% of cases. Adverse effects were seen in 11 patients, including infection of the donor site (5 cases), keloid formation (3) and hypopigmentation (3).Conclusion:
Autoinoculation may be an effective therapeutic modality for cutaneous warts and two sessions may be required for optimum results.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Placebos
/
Skin Diseases
/
Female
/
Humans
/
Male
/
Warts
/
Randomized Controlled Trials as Topic
/
Vaccination
/
Combined Modality Therapy
/
Adult
Type of study:
Controlled clinical trial
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2014
Type:
Article
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