Carnitine supplementation in diphtheria.
Indian Pediatr
;
1992 Dec; 29(12): 1501-5
Article
in English
| IMSEAR
| ID: sea-15574
ABSTRACT
We studied the effect of carnitine supplementation in patients with diphtheria. Six hundred and twenty five children of diphtheria received either DL-carnitine (100 mg/kg/day in two divided doses orally for four days), or no carnitine, in addition to the routine treatment for diphtheria. The patients receiving carnitine (n = 327) and controls (n = 298) were matched for age, sex, duration of symptoms, grade of toxemia and immunization status. Patients receiving carnitine showed a significant reduction in incidence of myocarditis as compared to controls (p = 0.001). Cases with myocarditis receiving carnitine therapy showed a significant reduction in mortality as compared to controls (p < 0.001). In view of a significant decline in incidence and mortality of myocarditis in cases of diphtheria, we recommended that all cases with diphtheria should receive carnitine supplementation.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Brazil
/
Female
/
Humans
/
Male
/
Carnitine
/
Child
/
Child, Preschool
/
Incidence
/
Diphtheria
/
Infant
Type of study:
Controlled clinical trial
/
Incidence study
/
Prognostic study
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Indian Pediatr
Year:
1992
Type:
Article
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