Mutation profiling in gallbladder cancer in Indian population.
Indian J Pathol Microbiol
;
2014 Jan-Mar 57 (1): 9-12
Article
in English
| IMSEAR
| ID: sea-155960
ABSTRACT
Aim:
Gallbladder cancer is an aggressive malignancy usually diagnosed at late stage. The molecular genetics of this cancer is heterogeneous and not well established. Mutation profi ling of gallbladder cancer was performed through massarray technology with an aim to identify molecular markers involved in the tumor pathogenesis that can be helpful as markers for early diagnosis and targets for therapy. Materials andMethods:
Forty nine cases of gallbladder cancer were screened through Sequenom Massarray technology for 390 mutations across 30 genes in formalin fi xed paraffi n embedded archived tissues and the results of mutation profi ling was correlated with tumor characteristics. Mutations were observed in 9 of 49 cases across four genes – TP53 (four cases), CTNNB1 (two cases), PIK3CA (two cases), and KRAS (one case). Six of these cases were well differentiated but of eight of them belonged to stage II to IV disease. Six cases had associated gallstones.Conclusion:
The mutation frequency found in gallbladder cancer is comparable to the data available in literature. Identifi cation of PIK3CA and KRAS mutations would help in formulating more effi cacious targeted approach for management. Studies with large number of cases would help in exploring more targets and better classifi cation of these cancers at genetic level.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Prognostic study
/
Screening study
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2014
Type:
Article
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