Primary primitive neuroectodermal tumor of kidney: A rare case report with diagnostic challenge.
Indian J Pathol Microbiol
;
2014 Apr-Jun 57 (2): 298-300
Article
in English
| IMSEAR
| ID: sea-156036
ABSTRACT
Primary primitive neuroectodermal tumors (PNETs) of the kidney are quite rare and can be mistaken for a wide variety of other small round blue cell tumors which includes rhabdomyosarcoma, Wilm’s tumor, carcinoid, neuroblastoma, clear cell sarcoma of the kidney, lymphoma etc. Renal Ewings/PNET can occur in the age group from 4 to 61 years. Approximately, 90% of Ewing sarcoma (ES)/ PNET have a specifi c t(11;22) which results in a chimeric EWS-FLI-1 fusion protein. Immunohistochemical for the carboxy-terminus of FLI-1 is sensitive and highly specifi c for the diagnosis of ES/PNET. Herein, we have an interesting presentation in a 23-year-old male who came with neck pain and progressive quadriparesis and was diagnosed as a case of poorly differentiated malignant tumor with a differential of lymphoma versus metastatic renal cell carcinoma. The patient’s condition deteriorated fast and he had a rapid downhill course. The fi nal diagnosis of Ewings/PNET was confi rmed at autopsy.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Diagnostic study
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2014
Type:
Article
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