Regulation of N-Myristoyltransferase by the Calpain and Caspase Systems.
Indian J Biochem Biophys
;
2014 Dec ; 51(6): 506-511
Article
in English
| IMSEAR
| ID: sea-156530
ABSTRACT
N-myristoyltransferase (NMT) is an essential eukaryotic enzyme which catalyzes the transfer of the myristoyl group to the terminal glycine residue of a number of proteins including those involved in signal transduction and apoptotic pathways. In higher eukaryotes, two isoforms of NMT have been identified (NMT1 and NMT2) which share about 76% amino acid sequence identity in humans. Protein-protein interactions of NMTs reveal that m-calpain interacts with NMT1 whereas caspase-3 interacts with NMT2. These findings reveal differential interactions of both isoforms of NMT with various signaling molecules. This minireview provides an overview of the regulation of N-myristoyltransferase by calpain and caspase systems.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Acyltransferases
/
Calpain
/
Signal Transduction
/
Gene Expression Regulation, Enzymologic
/
Caspases
/
Lipid Metabolism
/
Animals
/
Models, Biological
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Biochem Biophys
Year:
2014
Type:
Article
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