Challenges of Ionizing Radiation in Tumor Treatment and Role of Angiogenesis.
Article
in English
| IMSEAR
| ID: sea-156533
ABSTRACT
Ionizing radiation is a non-specific, but most widely used therapeutic method for cancer treatment. However, a minor fraction of tumor cell population manages to survive after radiation. Radiation efficacy depends on adequate oxygen supply. Rapid growing tumors cause hypoxia that upregulates many pro-survival pathways. At clinical doses, radiation activates inflammatory pathways and causes oxidative stress that plays a positive role during angiogenesis. Selective targeting of signaling mechanisms may radiosensitize tumors.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Oxygen
/
Radiation, Ionizing
/
Humans
/
Cell Hypoxia
/
Cytokines
/
Treatment Outcome
/
Models, Immunological
/
Radiotherapy, Conformal
/
Cell Proliferation
/
Animals
Language:
English
Year:
2014
Type:
Article
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