Study of Routine Biochemistry Analytes in Leptospirosis for Evaluating Organ and System Specific Involvement.

ABSTRACT

During 1988-1997 there were 527 cases of Leptospirosis out of which 104 were fatal in south Gujarat, mainly due to liver and renal failure. Pulmonary involvement, though uncommon, led to high mortality. 90% present of patients of leptospirosis have anicteric leptospirosis while only 10% patients of leptospirosis have icteric leptospirosis, a more severe type. Methods and Results: Laboratory reports of samples of patients of Leptospirosis from July 2010 to August 2011 at Biochemistry laboratory of New Civil Hospital were collected from the Laboratory Database. Result: Out of 1293 number of samples of Leptospirosis patients, received at Biochemistry laboratory of New Civil Hospital, Surat. ALT in 71.4 %, Total Bilirubin in 71.8 %,Direct Bilirubin in 89.7 %, Creatinine in 64.3 % and Amylase in 72 % were found elevated. This study shows that 63% of patients have abnormal Liver function and 78% of patients with pancreatic involvement in agreement with a study by Atanasova M G which shows that increased amylase levels are seen in 41.67% of mild cases, in 25% of moderate cases and in 88.24% of severe cases. Conclusion: This study shows that majority of cases of leptospirosis at New Civil Hospital Surat (a tertiary care centre) are icteric leptospirosis and a large majority of them have pancreatic involvement.