A Comparative Study of Alanine Aminotransferase & Alkaline Phosphatase in Type-2 DiabeticPatients and Non-Diabetics.

ABSTRACT

Background: The aim of this study was to find out the liver function test abnormalities in a group of diabetic type-2 patients in Jamnagar, Gujarat and to determine the factors associated with these biochemical changes. Method: In this cross sectional study conducted at the diabetic clinic in GGH General Hospital, Jamnagar between May 2012 and April 2013, a total of 100 patients were included. Parameters like serum alanine aminotransferase (ALT), alkaline phosphatase (ALP) used. Result: Raised ALT was noted in 30 % of diabetes type -2 patients while in control group 6% had elevated value. Elevations in serum alkaline phosphatase (ALP) were found in 38 %. Mean value of ALT & ALP had no correlation with gender of the diabetes patients. In conclusion, abnormal liver function results are more common among diabetes patients. Elevated ALT and ALP are the markers for associated non alcoholic fatty liver disease in diabetes patients.