Rising trend of antimicrobial resistance among Neisseria gonorrhoeae isolates and the emergence of N. gonorrhoeae isolate with decreased susceptibility to ceftriaxone.
Indian J Med Microbiol
;
2015 Jan-Mar ; 33 (1): 39-42
Article
in English
| IMSEAR
| ID: sea-156987
ABSTRACT
Context Gonorrhoea is one of the most common sexually transmitted infections (STI) in developing countries and is a global health problem. Aims:
To analyze the trend of antimicrobial susceptibility of Neisseria gonorrhoeae isolates over the years, in a tertiary care hospital of North India. Settings andDesign:
The study population comprised males with urethritis and females with endocervicitis attending STI clinic of our hospital. Materials andMethods:
In our STI laboratory, all gonococcal isolates are subjected to antimicrobial susceptibility testing by disc diffusion method as per CLSI guidelines. ß-lactamase production is determined by chromogenic cephalosporin test. Minimum Inhibitory Concentration (MIC) for ceftriaxone is determined by E-test. Statistical Analysis Used Data were expressed as percentages. The differences in percentages were tested for statistical signifi cance by using χ2 test and P values were determined.Results:
The percentage of penicillinase producing N. gonorrhoeae (PPNG) increased from 8% in 1995-96 to 20% in 2004-05 and 88% in 2011-2013. Quinolone-resistant N. gonorrhoeae (QRNG) showed a signifi cant increase from 12% in 1995-96 to 98.3% in 2004-05, while 84% isolates were found to be QRNG by 2011-2013. In January 2013 we detected our fi rst gonococcal isolate with decreased susceptibility to third-generation cephalosporins; Ceftriaxone, Cefi xime and Cefpodoxime (MIC for ceftriaxone = 0.19 μg/ml).Conclusions:
The results of our study highlighted an alarming increase in the percentage of PPNG and QRNG strains over the years. Emergence of N. gonorrhoeae isolates with decreased susceptibility to third-generation cephalosporins is a cause of concern and thus emphasises the importance of antimicrobial susceptibility testing.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Practice guideline
Language:
English
Journal:
Indian J Med Microbiol
Journal subject:
Microbiology
Year:
2015
Type:
Article
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