Weak D antigen - Revisited.
Article
in English
| IMSEAR
| ID: sea-157332
ABSTRACT
D antigen is the most immunogenic antigen in the complex Rh blood group system discovered in the year 1939. There is a lot of polymorphism in its phenotype due to genetic heterogeneity. Certain mutations and /or deletions lead to a weak phenotype defined by decreased density of antigen sites which require the use of anti human globulin for detection. The need for detection of the weak D antigen was to prevent alloimmunization by this blood if transfused to a D negative patient especially to women in child bearing age group. This contention is however, controversial and not proven beyond doubt. Moreover, the use of potent monoclonal D typing antisera detects low density of weak D antigens thus obviating the use of anti human globulin. We have assessed the incidence of Rh negative and weak D blood groups in the Garhwal region of Uttarakhand and reviewed the literature regarding the controversies in the clinical significance of weak D antigen.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rh-Hr Blood-Group System
/
Rh Isoimmunization
/
Female
/
Humans
/
Immunoglobulins
/
Blood Grouping and Crossmatching
/
Incidence
/
Immunization
/
Globulins
/
India
Type of study:
Incidence study
/
Prognostic study
Country/Region as subject:
Asia
Language:
English
Year:
2011
Type:
Article
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