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Protective Effect of Ethyl Acetate Extract of Acacia Catechu in Carbon Tetrachloride Induced Hepatotoxicity.
Article in English | IMSEAR | ID: sea-157400
ABSTRACT

Objective:

To study the protective effect of ethyl acetate extract of Acacia catechu in carbon tetrachloride induced hepatotoxicity in albino rats.

Methods:

The liver damage in albino rat was induced by a subcutaneous injection of 50%v/ v carbon tetrachloride in olive oil at the dose of 2ml/kg twice a week for 14days. The hepatoprotective activity was monitored biochemically by estimating serum transaminases, serum alkaline phosphatase, serum bilirubin and serum protein after intraperitoneal injection of ethyl acetate extract of Katha(250mg/kg). Silymarin(5mg/kg.I.P) was given as a reference drug. The histopathological changes of liver samples were compared with that of control.

Results:

Ethyl acetate extract of Acacia catechu inhibited carbon tetrachloride induced liver toxicity in albino rats at 250mg/kg body weight as assessed by the biochemical and histological examination.

Conclusion:

Ethyl acetate extract of “Katha” exhibited significant hepatoprotective activity.
Subject(s)

Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Silymarin / Carbon Tetrachloride / Plant Extracts / Adult / Acacia / Chemical and Drug Induced Liver Injury / Liver / Animals / Acetates Language: English Year: 2012 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Silymarin / Carbon Tetrachloride / Plant Extracts / Adult / Acacia / Chemical and Drug Induced Liver Injury / Liver / Animals / Acetates Language: English Year: 2012 Type: Article