Protective Effect of Ethyl Acetate Extract of Acacia Catechu in Carbon Tetrachloride Induced Hepatotoxicity.
Article
in English
| IMSEAR
| ID: sea-157400
ABSTRACT
Objective:
To study the protective effect of ethyl acetate extract of Acacia catechu in carbon tetrachloride induced hepatotoxicity in albino rats.Methods:
The liver damage in albino rat was induced by a subcutaneous injection of 50%v/ v carbon tetrachloride in olive oil at the dose of 2ml/kg twice a week for 14days. The hepatoprotective activity was monitored biochemically by estimating serum transaminases, serum alkaline phosphatase, serum bilirubin and serum protein after intraperitoneal injection of ethyl acetate extract of Katha(250mg/kg). Silymarin(5mg/kg.I.P) was given as a reference drug. The histopathological changes of liver samples were compared with that of control.Results:
Ethyl acetate extract of Acacia catechu inhibited carbon tetrachloride induced liver toxicity in albino rats at 250mg/kg body weight as assessed by the biochemical and histological examination.Conclusion:
Ethyl acetate extract of “Katha” exhibited significant hepatoprotective activity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Silymarin
/
Carbon Tetrachloride
/
Plant Extracts
/
Adult
/
Acacia
/
Chemical and Drug Induced Liver Injury
/
Liver
/
Animals
/
Acetates
Language:
English
Year:
2012
Type:
Article
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