Study of Lipid Profile and Glycated Hemoglobin in Diabetes Mellitus.

ABSTRACT

Background: Pattern of dyslipidemia is found to be different in type-1 & type-2 diabetes mellitus(DM). Dyslipidemic pattern and its correlation with glycated hemoglobin in both types of diabetes mellitus has been well studied and might be informative to the diagnostic,therapeutic & prognostic aspects of diabetes mellitus. AIM: To study the lipid profile by using direct method for High Density Lipoprotein-Cholesterol (HDLC) & Low Density Lipoprotein-Cholesterol(LDL-C) estimation, and glycated hemoglobin(GHb) in type-1DM & type-2 DM. Material and Methods: fifty each already diagnosed patients of type-1 and type-2 diabetes mellitus along with fifty control were studied for lipid profile using direct method for Low Density Lipoprotein-Cholesterol (LDL-C) & High Density Lipoprotein-Cholesterol (HDLC) estimation and glycated hemoglobin status. Statistical Analysis: we used student t-test and Pearson’s correlation coefficient to find the statistical significance. Result: serum concentration of glycated hemoglobin and all the parameters of lipid profile except HDL-C were increased while HDL-C concentration decreased in both the types of DM as compared to that of control. Conclusion: dyslipidemia is more prominent in type-2 DM than that in type-1 DM . Glycemic control is poorer & its correlation with lipid profile is stronger in type-2 DM as compared to type-1 DM.