Effect of Risperidone on Lipid Profile and Related Risk for Coronary Heart Disease.

ABSTRACT

Present study was carried out in a view to studing the effect of Risperidone used for treatment of Schizophrenia on Lipid Profile and, its related risk for coronary heart disease, in 30 patients on Risperidone and compared with 30 age and sex matched healthy controls. We found that this drug significantly does not increase the risk for coronary heart disease in patients with respect to lipid profile and other parameters as described by Framingham study group by estimating Framingham Point Scores. Nor it has much effect on lipid profile, except that triglyceride shows significantly higher levels (187.1 ± 24.73) as compared to controls (135.9 ± 25.05) with p value <0.001. Altogether, this drug is safe for these patients, but long-term implications of these findings need to be studied, as prevalence of CHD is increasing day-by-day due to the globalization.