Effects of Emblica Officinalis (AMLA) on Serum Lipids and Atherogenesis in Albino Rats Fed with High Fat Diet.
Article
in English
| IMSEAR
| ID: sea-157528
ABSTRACT
Objective:
To evaluate the effects of Emblica officinalis (Amla) extract on serum lipids and atherogenesis, in albino rats fed with high fat diet. Materials andMethods:
Healthy albino rats of Wistar strain (150-200 gm each) were randomized into five groups of six animals each- Group A (received normal diet), Group B (received normal diet + Emblica officinalis extract 1 gm/kg BW) Group C (received high fat diet consisting of vanaspati ghee and coconut oil at a ratio of 32, at a dose of 10 ml/kg/day), Group D (received high fat diet + Emblica officinalis extract 1 gm/kg BW) and Group E (received high fat diet + simvastatin 1.8 mg/ kg BW). Treatment period was 8 weeks. At the end of 8 weeks, lipid profile was evaluated by estimating total cholesterol, serum triglyceride, serum LDL, serum HDL and atherogenic index.Results:
Ethanolic extract of Emblica officinalis showed significant antihyperlipidaemic activity (P< 0.01) with significant improvement in atherogenic index (p<0.01).Conclusion:
Present study suggests that Emblica officinalis extract at a dose of 1 gm/kg BW exerts antihyperlipidaemic effect comparable to that of simvastatin. It also possesses hypolipidaemic activity.
Full text:
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Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Plant Extracts
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Rats, Wistar
/
Simvastatin
/
Phyllanthus emblica
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Atherosclerosis
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Diet, High-Fat
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Hyperlipidemias
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Lipids
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Animals
Language:
English
Year:
2013
Type:
Article
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