Spectrum of Histopathological Findings in Liver Biopsy.

ABSTRACT

The significance of abnormal liver function tests in the absence of diagnostic serology is unclear. The aim of this prospective study is to report liver biopsy findings in a large group of patients with unexplained abnormal liver biochemistry and correlate them with the clinical features to assess the severity of these diseases. Percutaneous liver biopsy is a relatively safe and accurate method of diagnosing liver disease and should be considered in such cases. A total of 65 liver biopsies were studied, of which, 26.15% (n=17) hepatic tumors, 23.08% (n=15) cirrhosis, 20.00% (n=13) fatty liver and 06.15% (n=4) viral hepatitis were seen. Further, 01.54% case (n=1) each of alcoholic hepatitis, benign recurrent intrahepatic cholestasis, extrahepatic biliary atresia, granulomatous hepatitis, neonatal hepatitis, Niemann-Pick disease and secondary biliary cirrhosis were also observed. Liver biopsy was non specific in 9.23% (n=6) and inadequate in 4.62% (n=3) cases .The role of histopathological examination of liver biopsy is highlighted in this paper.