Cord Serum Screening Test and the Newborns Allergic Status.
Indian Pediatr
;
2009 Apr; 46(4): 295-299
Article
in English
| IMSEAR
| ID: sea-15794
ABSTRACT
OBJECTIVE:
To evaluate the predictive value of a cord serum screen test and possible subsequent development of allergic disease in infants.DESIGN:
Cohort study.SETTING:
100 pregnant women were randomly recruited for the study.METHODS:
The maternal serum and the cord serum of their matched newborn were analyzed for total serum immunoglobulin E (IgE), gamma interferon (g IFN), house dust mite- Dermatophagoides pteronyssinus allergen (Der p1) and Blomia tropicalis allergen (Blo t5) using immunoassay methods. All infants were followed up for one year.RESULTS:
Infants who had allergic diseases in the one year follow-up (n=45) had significantly (P < 0.001) elevated IgE, Der p1, Blo t5, and significantly low g IFN levels in cord serum as compared to the same parameters of infants who did not develop allergic disease in the one year follow-up (n=43).CONCLUSION:
In utero exposure to HDM allergens Der p1 and Blot5 is prevalent. We have successfully established a cord serum screening test for predicting allergic diseases in infancy with 93% specificity and sensitivity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Immunoglobulin E
/
Infant, Newborn
/
Pregnancy
/
Cysteine Endopeptidases
/
Allergens
/
Predictive Value of Tests
/
Follow-Up Studies
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Screening study
Language:
English
Journal:
Indian Pediatr
Year:
2009
Type:
Article
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