Fabrication and evaluation of ethyl cellulose and cellulose acetate coated controlled release multiparticulate formulation of ketoprofen by dry powder layering technology.

ABSTRACT

Multiparticulate is one of the most widely accepted technologies in the pharmaceutical industries. Present study aim is to prepare controlled release multiparticulate of Ketoprofen by drug powder layering technology using two different release retardant (Ethyl Cellulose & Cellulose Acetate) in five different drug release retardant concentrations (5%, 10%, 20%, 30% & 40%). The most widely used multiparticulate system in pharmaceutical industries is Dry Powder Layering Technique. Powder layering involves the deposition of successive layers of dry powder(s) and excipients on preformed nuclei or cores with the help of binding liquids. The prepared multiparticles were evaluated for friability, drug content uniformity, density and percentage yield. The release rate was evaluated by dissolution studies. To establish drug polymer compatibility DSC and FT IR was done. Study concluded that Dry Powder Layering of Ketoprofen can be effectively used for drug loading on non-pareil seeds. It was also found that formulation having Ethyl Cellulose have more retarding capacity than the Cellulose Acetate in both formulations and drug release follows Zero order kinetics. DSC and FT IR study concluded that there is no interaction between EC and CA. From dissolution parameter of the prepared multiparticles it is concluded that formulation EC3 (20%) and CA4 (30%) posses the required characteristics of oral controlled release formulation. It is assumed that above 90% of the drug will be released within 24 hours. Hence this formulation can be used as once daily dosage regimen for the controlled release of Ketoprofen.