Association of insulin resistance with redox imbalance in patients with non diabetic hypertension.

ABSTRACT

Oxidative stress involved in the pathogenesis of several diseases. Hypertension itself acts as source of oxidative stress. Insulin resistance is involved in the pathogenesis of essential hypertension. In the present study an attempt was made to study the association between insulin resistance and oxidative stress in non diabetic hypertensive patients. Two hundred and three, non diabetic hypertensive patients and two hundred and ten, healthy normotensive subjects were enrolled in this study. Malondialdehyde, reduced glutathione, glutathione peroxidase, Fasting insulin and HOMA-IR levels were estimated in both groups. Fasting insulin, reduced glutathione, glutathione peroxidase and MDA shows significant difference between cases and controls. Among the patients HOMA-IR were significantly correlated with lipid peroxides and shows negative correlation between HOMAIR and glutathione peroxidase. Increased HOMA-IR was found in non diabetic hypertensive patients. This study reveals the link between oxidative stress and insulin resistance.