Spontaneous regression in an ulcerated CK7 positive Merkel cell carcinoma.
Indian J Dermatol Venereol Leprol
;
2015 Mar-Apr; 81(2): 170-173
Article
in English
| IMSEAR
| ID: sea-158275
ABSTRACT
Merkel cell carcinoma is an aggressive and frequently lethal tumor of the elderly, associated with sun exposure and immunosuppression which is less common in the dark-skinned. We report the case of a 40-year-old woman who presented with multiple slowly progressive, mildly itchy ulcerated plaques of size ranging from 2 × 3 cm to 5 × 7 cm on the left knee of 1 year duration. Skin biopsy showed diffuse dermal infi ltration by small round cells with molding of cells and lymphocyte infi ltration. The cells stained positive for cytokeratin (CK) 20, CK7, neuron-specifi c enolase, and chromogranin. The skin lesions underwent spontaneous regression within 1 month of skin biopsy and have not recurred during the past 2 years. The immune mechanisms triggered by biopsy possibly explain the spontaneous regression.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Remission, Spontaneous
/
Female
/
Humans
/
Adult
/
Keratin-7
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2015
Type:
Article
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