Addition of citral controls ROS and reduces toxicity in 5-fluo rouracil treated Schizosaccharomyces pombe cells.
Indian J Exp Biol
;
2015 Mar; 53(3): 152-157
Article
in English
| IMSEAR
| ID: sea-158403
ABSTRACT
In systemic therapy, chemotherapeutic drugs, often, cause considerable side effects; and combination of natural compounds lessen the extent of such effects. In the present study, combined effect of citral and 5-fluorouracil was studied in Schizosaccharomyces pombe cells. The antagonistic combination index found was at 0.01 and 0.025 mM of citral with 40 µg or higher concentration of 5-fluorouracil. The combined treatment was so effective that higher number of cells underwent apoptosis compared to individual treatment of 5-fluorouracil. Citral controlled ROS levels and increased survival of normal cells. Several differentially expressed proteins observed in the citral treatment could further help understanding its mechanism of action.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Schizosaccharomyces
/
Fungal Proteins
/
Reactive Oxygen Species
/
Apoptosis
/
Oxidative Stress
/
Monoterpenes
/
Dose-Response Relationship, Drug
/
Drug Evaluation, Preclinical
/
Fluorouracil
Language:
English
Journal:
Indian J Exp Biol
Year:
2015
Type:
Article
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