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Addition of citral controls ROS and reduces toxicity in 5-fluo rouracil treated Schizosaccharomyces pombe cells.
Indian J Exp Biol ; 2015 Mar; 53(3): 152-157
Article in English | IMSEAR | ID: sea-158403
ABSTRACT
In systemic therapy, chemotherapeutic drugs, often, cause considerable side effects; and combination of natural compounds lessen the extent of such effects. In the present study, combined effect of citral and 5-fluorouracil was studied in Schizosaccharomyces pombe cells. The antagonistic combination index found was at 0.01 and 0.025 mM of citral with 40 µg or higher concentration of 5-fluorouracil. The combined treatment was so effective that higher number of cells underwent apoptosis compared to individual treatment of 5-fluorouracil. Citral controlled ROS levels and increased survival of normal cells. Several differentially expressed proteins observed in the citral treatment could further help understanding its mechanism of action.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Schizosaccharomyces / Fungal Proteins / Reactive Oxygen Species / Apoptosis / Oxidative Stress / Monoterpenes / Dose-Response Relationship, Drug / Drug Evaluation, Preclinical / Fluorouracil Language: English Journal: Indian J Exp Biol Year: 2015 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Schizosaccharomyces / Fungal Proteins / Reactive Oxygen Species / Apoptosis / Oxidative Stress / Monoterpenes / Dose-Response Relationship, Drug / Drug Evaluation, Preclinical / Fluorouracil Language: English Journal: Indian J Exp Biol Year: 2015 Type: Article