Decreased keratocyte density and central corneal thickness in primary open‑angle glaucoma patients undergoing treatment with topical prostaglandin analogues.
Indian J Ophthalmol
;
2015 Jan; 63(1): 15-19
Article
in English
| IMSEAR
| ID: sea-158491
ABSTRACT
Purpose:
To evaluate whether prostaglandin (PG) analogue use is associated with alterations in keratocyte density and central corneal thickness (CCT) in subjects with primary open‑angle glaucoma (POAG). Materials andMethods:
Thirty‑five POAG patients treated with PG analogues for >2 years and 35 control subjects without glaucoma were included in this cross‑sectional study. All subjects were underwent CCT measurements using ultrasound pachymetry. Keratocyte densities of each stromal layer were determined by in vivo confocal microscopy. Student’s t‑test and Chi‑square test were used for statistical evaluations. Correlations between keratocyte densities and CCT were analyzed using Pearson’s correlation analysis.Results:
Keratocyte densities in each stromal layer were significantly lower in glaucoma patients receiving PG analogues as compared to those of controls (P < 0.001). The mean CCT was also lower in glaucoma patients (515.2 ± 18.8 μ) than control subjects (549.6 ± 21.1 μ, P < 0.001). A positive correlation between keratocyte densities in each stromal layer and CCT was observed in POAG patients.Conclusions:
Long‑term administration of topical PG analogues may adversely influence keratocyte densities and CCT. Further prospective studies are required clarify the relationship between PG analogues and their effects on the cornea.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Observational study
/
Risk factors
Language:
English
Journal:
Indian J Ophthalmol
Year:
2015
Type:
Article
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