Efficacy and Tolerability of Escitalopram for Treating Depression in Parkinson’s Disease.
Article
in English
| IMSEAR
| ID: sea-159550
ABSTRACT
Introduction:
Despite the frequently coexistence and prominent negative effect of depression in Parkinson’s disease, there is currently no evidence-based standard of care.Objective:
The purpose of this study was to examine the efficacy and tolerability of individually administered selective serotonin reuptake inhibitor (SSRI) - escitalopram, relative to clinical monitoring (with no new treatment), for depression in this medical population.Method:
In this retrospective open label analysis of 28 depressed (based on ICD-10 criteria and Mini International Neuropsychiatric Interview) patients with Parkinson’s disease were treated with escitalopram 10-20 mg/d for duration of 8 weeks. The Hospital Anxiety and Depression Scale (HADS) depression subscale score and Clinical Global Impression-Improvement (CGI-I) score was the primary outcome. Assessments were completed at baseline, 4 (midpoint) and 8 (end of treatment) weeks of follow-up evaluation.Results:
Although treatment was well tolerated and correlated with a significant decrease in HADS and CGI score, response and remission rates were 43.4% and 57.2%, respectively.Conclusions:
Escitalopram may be a viable approach for the treatment of depression in Parkinson’s disease. Further research is needed to replicate and extend these findings.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Parkinson Disease
/
Humans
/
Citalopram
/
Depression
/
Dose-Response Relationship, Drug
/
Drug Evaluation, Preclinical
/
Drug Tolerance
Language:
English
Year:
2012
Type:
Article
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