Delta-9-tetrahydrocannabinol and human spermatozoa.

ABSTRACT

The in vitro effect of Δ9-tetrahydrocannabinol on adenosine triphosphatase and phosphodiesterase activities as well as on the cyclic-AMP content of human spermatozoa has been studied. At a concentration of 1·0 μg, sperm metabolism may be increased as shown by increased cyclic AMP and adenosine-triphosphatase activity while at a higher concentration (10 μg tetrahydrocannabinol), it may be reversed.