Survival of orally administered isolated intestinal Lactobacillus acidophilus in different parts of gastrointestinal tract of mice.

ABSTRACT

A strain of Lactobacillus acidophilus (Strain HF) was isolated from human faeces. A chloramphenicol resistant strain (HFCm) and a strain (HFCmSm chloramphenicol and streptomycin were developed from the isolated strain (HF). All the ) restant to both Kyd Street, Calcutta 700 016 three strains showed similar in vitro susceptibility against host defence factors like gastric acid, bile salts and volatile as well as non-volatile fatty acids. In vivo tests were done by feeding these strains to mice. When the resistant strains were orally administered along with the antibiotic(s) they were stable up to 72 h.