Antiatherogenic effect of a low lysine: arginine ratio of protein involves alteration in the aortic glycosamihoglycans and glycoproteins.

ABSTRACT

The effect of alteration of lysine arginine ratio of the protein on the aortic glycosaminoglycans and glycoproteins was studied in rats fed cholesterol free and atherogenic diet. The concentration of total glycosaminoglycans and of individual fractions was significantly lower in the aorta in the case of diet with lysine arginine ratio of 1·0, than the diet with a ratio of 2·0. Rats fed globulin fraction isolated from sesame seeds, which has a lysine arginine ratio of 0·67 also showed significantly lower concentration of total and individual glycosaminoglycan fractions in the aorta than those fed casein (lysinearginine ratio 2·0). Concentration of total hexose and fucose in the glycoproteins was also lower in the aorta in the case of lysine arginine ratio 1·0. These results in the light of previous reports of increase in the aortic glycosaminoglycans in the early stages of atherosclerosis and increase in the total hexose and fucose in the glycoproteins in the atherosclerotic aorta indicate that the antiatherogenic effect of a low lysine arginine ratio in the protein involves alteration in the aortic glycosaminoglycans and glycoproteins.