Changes in insulin receptor, hexokinase and NADPH producing enzymes in Choroid plexus during experimental diabetes.

ABSTRACT

The activities of insulin receptor and the enzymes hexokinase (EC 2.7·1.1) and NADP-dependent malic enzyme (EC 1·1·1·40), glucose 6-phosphate dehydrogenase (EC 1·1·1·49) and isocitrate dehydrogenase (EC 1·1·1·42) were measured in rat choroid plexus in alloxan induced diabetes. A significant decrease was observed in the activities of all the enzymes except isocitrate dehydrogenase and also the choroid plexus insulin receptor activity was decreased. A reversal of the efect was observed with insulin administration to diabetic rats. It may be concluded that the enzymes of choroid plexus together with insulin receptor are directly controlled by-the concentration of insulin.