Pharmacophores of the dual acting α, β-blockers as deduced, from molecular dynamics simulations.
J Biosci
;
1996 Sept; 21(5): 599-611
Article
in English
| IMSEAR
| ID: sea-161121
ABSTRACT
The dual acting α, β-blockers have an important place in the management of hypertension. Molecular dynamics simulations have been carried out on all stereoisomers of seven dual acting α,β-blockers namely adimolol, amosulalol, bucindolol, carvedilol, labetalol, medroxalol and primidolol. Three families of conformations have been identified for the group of compounds. The pharmacophores for α and β-activity have been constructed for two of these families.
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Index:
IMSEAR (South-East Asia)
Language:
English
Journal:
J Biosci
Year:
1996
Type:
Article
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