Magnesium perchlorate [Mg (ClO4)2] catalyst one-pot synthesis of 3,4-DI hydropyrimidin-2(1H)-ones: an improved procedure for biginelli condensation.

ABSTRACT

3, 4-Dihydropyrimidinones were synthesized very efficiently in excellent yields, while using the magnesium perchlorate as catalyst. This protocol can be applicable to a wide range of aldehydes, ethylacetoacetate and urea. The reaction conditions were very mild and the isolation of products also very easy.