Estimation of sumatriptan succinate in bulk and formulations by visible spectrophotometry using aromatic aldehydes.

ABSTRACT

Two simple and sensitive visible spectrophotometric methods (A and B) have been developed for the determination of sumatriptan succinate in bulk and tablet dosage forms. Methods (A and B) are based on the reaction of drug with aromatic aldehydes such as Vanillin or Para dimethyl amino cinnamaldehyde(PDAC) in the presence of sulphuric acid in non aqueous medium and formed purple red colored condensation products with an absorption maximum of 565nm for method A and 560nm for method B. The Beer’s law obeyed in the concentration range of 10-50μg/ml for method A and 20-60μg/ml for method B. The proposed methods are applied to commercial available tablets and the results are statistically compared with those obtained by the reference method and validated by recovery studies.