Lamins, laminopathies and disease mechanisms: Possible role for proteasomal degradation of key regulatory proteins.
J Biosci
;
2011 Aug; 36(3): 471-479
Article
in English
| IMSEAR
| ID: sea-161566
ABSTRACT
Lamins are major structural proteins of the nucleus and are essential for nuclear integrity and organization of nuclear functions. Mutations in the human lamin genes lead to highly degenerative genetic diseases that affect a number of different tissues such as muscle, adipose or neuronal tissues, or cause premature ageing syndromes. New findings on the role of lamins in cellular signalling pathways, as well as in ubiquitin-mediated proteasomal degradation, have given important insights into possible mechanisms of pathogenesis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Journal:
J Biosci
Year:
2011
Type:
Article
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