Relation of calculated HbA1C with fasting plasma glucose and duration of diabetes.

ABSTRACT

Background and objectives Glycosylated hemoglobin (HbA1c) is a marker of evaluation of long-term glycemic control in diabetic patients and predict risks for the development and/or progression of diabetic complications. Glycosylation process depends on the exposure to glucose. Studies on chronic complications of diabetes established the role of glycosylated hemoglobin (HbA1c) as a marker of evaluation of long term glycemic control and risk for chronic complications. The aim of this study is to evaluate the significance of calculated HbA1c by using fasting plasma glucose levels and comparison with duration of diabetes mellitus. Materials and methods The present study has 2 groups of subjects, 27 normal and 32 diabetic subjects. The diabetic subjects were divided into 2 groups based on complication i,e cataract and nephropathy with duration of diabetes. Plasma glucose was estimated by GOD – POD method. Estimation of glycated hemoglobin was done by calculation. Results and conclusion We found the significance in the duration of diabetes and the levels of glycated hemoglobin and fasting glucose levels were significantly increased in diabetic group as compared to normal subjects (p<0.001). Thus, calculated HbA1c levels can be used with regular checkups of FPG and HbA1c levels in diabetic patients at lesser cost.