Oxidative stress, interleukin (IL-6) and atherogenic index of plasma in diabetic nephropathy.

ABSTRACT

Plasma IL-6 and serum MDA were significantly high in microalbuminuria and macroalbuminuria as compared to normal controls and normoalbuminuria. Plasma TAC was significantly decreased in all the groups of diabetic patients as compared to normal controls. Significant increase in lipid parameters and AIP were observed in macroalbuminuria and microalbuminuria as compared to normal controls. Plasma IL-6 showed negative correlation with HDL-c (r=-0.255) and significant positive correlation was observed between MDA and HbA1c (r=0.537) in diabetic patients. Conclusion: Increased IL-6, MDA levels and decreased plasma TAC levels in diabetic patients revealed inflammation with increased oxidative stress, which may involve in the development of renal damage. The associated altered lipid profile and high risk AIP indicates the risk of developing cardiovascular complications in diabetic patients with macroalbuminuria.