Protective role of coriandrum sativum (coriander) extracts against lead nitrate induced oxidative stress and tissue damage in the liver and kidney in male mice.

ABSTRACT

The present study describes antioxidant effect of Coriandrum sativum against lead nitrate induced toxicity in mice. Oxidative stress was induced in mice by a daily dose of lead nitrate (40 mg/kg body weight by oral gavage) for seven days. From day eight, after lead nitrate treatment, experimental animals received an oral dose of coriander extracts (aqueous extract - 300 mg/kg body weight and 600 mg/kg body weight; ethanolic extract - 250 mg/kg body weight and 500 mg/kg body weight) daily. The effect of these treatments in influencing the lead induced changes on hepatic and renal oxidative stress and biochemical changes along with histopathological alterations in soft tissues was studied. The data showed significant increase in liver and kidney LPO levels in animals treated with lead nitrate while the effect was attenuated by the plant extracts. Also, lead caused a significant decrease in antioxidant enzyme activity and this effect was reversed in groups treated with plant extract. Treatment with coriander significantly reduced the adverse effects related to most of biochemical parameters altered in animals treated with lead, related to hepatic and renal oxidative stress. Oral administration of Coriander to lead treated mice attenuated the deranged histopathological changes to some extent. It can be concluded from these results that Coriandrum sativum protects against lead toxicity and warrants the identification and isolation of active compounds responsible for its antioxidant effects.