TBARS level in socioeconomical poor rural sickle cell patients of Bilaspur Zone of Chhattisgarh State.
Article
in English
| IMSEAR
| ID: sea-161960
ABSTRACT
Sickle cell disease (SCD) is an inherited disorder of hemoglobin synthesis and the oxidative stress has major role in the pathogenesis of SCD. Thiobarbituric acid reactive substances formation by lipid peroxidation is a marker of oxidative damage in membrane.The study was under taken to measure the oxidative stress in sickle cell patients of Chhattisgarh rural population because of low natural antioxidants in their diet. The patients of sickle cell anemia group (homozygous, n=9) and sickle cell trait (heterozygous, n=21) shows TBARS level 2.28±0.66μM/l and 2.23±0.7μM/l respectively as compared to control (without S.C.D) 1.25±0.41μM/l. the study shows TBARS concentration is approximately double in sickle cell disease than control.
Full text:
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Index:
IMSEAR (South-East Asia)
Language:
English
Year:
2011
Type:
Article
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