Chitosan–sodium alginate nanocomposites blended with cloisite 30B as a novel drug delivery system for anticancer drug curcumin.

ABSTRACT

In the present research program, polymer nanocomposites have been used as the drug carrier for delivery systems of anticancer drug. Chitosan (CS) and sodium alginate (ALG) with different ratios were blended with different wt% of Cloisite 30B solution by solvent evaporation method. Cloisite 30B was incorporated in the formulation as a matrix material component which also plays the role of a co-emulsifier in the nanocomposite preparation. Curcumin with different concentrations were loaded with CS-ALG/ C 30B nanocomposites for studying the in-vitro drug delivery systems. Morphology and structure characterization of nanocomposites were investigated by X-Ray Diffraction (XRD), Scanning Electron Microscope (SEM) and Fourier Transmission Infra Red Spectroscopy (FTIR) respectively. The drug release was studied by changing time, pH and drug concentrations. The kinetics of the drug release was studied in order to ascertain the type of release mechanism. Based on the diffusion as well as the kinetics, the mechanism of the drug release from the composite matrix has been reported.