The effect of acetylsalicylic acid on hematological and biochemical parameters in female albino rats.

ABSTRACT

The present investigation is aiming at studying the effect of oral administration of aspirin (acetylsalicylic acid, ASA) drug on female albino rat, Rattus rattus norvegicus. The female rats (n=24) were allocated into 2 groups as control and treated. The treated rats (n=12) were given orally with high dose of aspirin at a dose of 100 mg/ kg body weight for 15 days (n=6) and 30 days (n=6). And body weight, relative organ weights, hematological parameters such as Hb %, total count RBC and total count WBC; and biochemical estimations in blood serum such as glucose, protein, cholesterol and calcium were measured. The aspirin did not showed much significant variations in the body weight, relative organ weights, serum protein, serum cholesterol, serum calcium, total counts RBC and Hb %; while, aspirin declined serum glucose level and elevated total count of WBC. The present investigation indicated that the aspirin impairs serum glucose level and total count of WBC by modulating of certain enzymes metabolism in albino rats.