A comparative solubility enhancement study of rosuvastatin using solubilization techniques.

ABSTRACT

Solid dispersion of Rosuvastatin was prepared by solvent evaporation method; PEG (Polyethylene glycol) 4000, mannitol and urea were used as carriers. Hydrotropic studies were carried out using different hydrotropic agents (sodium acetate, sodium benzoate and salicylate) and Micellar solubilization was carried out using different surfactant solutions (sodium lauryl sulphate, tween 80 and cetrimide).The solubility enhancement of Rosuvastatin by different solubilization technique was observed in decreasing order as hydrotropic solubilization > solid dispersion > micellar solubilization. It was observed that the solubility increased with the increase in the concentration of hydrotropic agents and amongst the various hydrotropic agents used the solubility was Rosuvastatin was enhanced greatest to 55 folds with sodium salicylate. This increase may be attributed due to aggregation of the hydrotropic molecules and inclusion of one of these aggregates at high concentration probably by reacting to form an associated product as a result of hydrogen bonding.