Effect of dexmeditomidine on postoperative junctional ectopic tachycardia after complete surgical repair of tetralogy of Fallot: A prospective randomized controlled study.
Ann Card Anaesth
;
2015 Jul; 18(3): 323-328
Article
in English
| IMSEAR
| ID: sea-162331
ABSTRACT
Introduction:
Incidence of junctional ectopic tachycardia (JET) after repair of tetralogy of Fallot (TOF) is 5.6–14%. Dexmeditomidine is a α-2 adrenoceptor agonist modulates the release of catecholamine, resulting in bradycardia and hypotension. These effects are being explored as a therapeutic option for the prevention of perioperative tachyarrhythmia. We undertook this study to examine possible preventive effects of dexmedetomidine on postoperative JET and its impact on the duration of ventilation time and length of Intensive Care Unit stay.Methods:
After obtaining approval from the hospitals ethics committee and written informed consent from parents, this quasi-randomized trial was initiated. Of 94 patients, 47 patients received dexmedetomidine (dexmedetomidine group) and 47 patients did not receive the drug (control group).Results:
Dexmedetomidine group had more number of complex variants like TOF with an absent pulmonary valve or pulmonary atresia (P = 0.041). Hematocrit on cardiopulmonary bypass (CPB), heart rate while coming off from CPB and inotrope score was significantly low in the dexmedetomidine group compared to control group. The incidence of JET was significantly low in dexmedetomidine group (P = 0.040) compared to control group.Conclusions:
Dexmedetomidine may have a potential benefit of preventing perioperative JET.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Tetralogy of Fallot
/
Tachycardia, Ectopic Junctional
/
Female
/
Humans
/
Male
/
Child, Preschool
/
Dexmedetomidine
Type of study:
Controlled clinical trial
Language:
English
Journal:
Ann Card Anaesth
Year:
2015
Type:
Article
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