Association of Polymorphisms in DAZL Gene with Male Infertility.
Br J Med Med Res
;
2013 Jan-Mar; 3(1): 41-48
Article
in English
| IMSEAR
| ID: sea-162783
ABSTRACT
Objectives:
To investigate the association between A260G (Thr12Ala) and A386G (Thr54Ala) single nucleotide polymorphisms (SNPs) in deleted in azoospermia-like gene (DAZL) and infertility in Jordanian males.Methods:
Infertile 170 patients with azoospermia or oligozoospermia and 176 fertile subjects were recruited in the study. DAZL SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP).Results:
The data showed that the A260G SNP is common in the Jordanian population with frequency of 10.3% for 260G mutant allele. However, the A386G SNP is absent in the studied population. No significant association was found between the examined SNPs in DAZL gene and men infertility.Conclusion:
The A260G and A386G polymorphisms of DAZL seem to play no role in men infertility in Jordanian population.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Journal:
Br J Med Med Res
Year:
2013
Type:
Article
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