Is the Total Score of the Hamilton Depression Rating Scale Associated with Suicide Attempts or Suicides.
Br J Med Med Res
;
2013 Jan-Mar; 3(1): 140-152
Article
in English
| IMSEAR
| ID: sea-162798
ABSTRACT
Background:
Most evidence behind interventions for depression is, in essence, based on the total score of the 17-item Hamilton Depression Rating Scale (HDRS). We identified no systematic review or meta-analysis examining if a total 17-item HDRS score is associated with suicide attempts or suicides in depressive patients.Methodology:
Based on a systematic literature search CENTRAL in The Cochrane Library, MEDLINE, EMBASE, PsycInfo, and Science Citation Index Expanded, we systematically reviewed and meta-analysed observational studies examining if the total 17-item HDRS score is associated with suicide attempts or suicides.Results:
We identified and included ten cohort studies - seven retrospective and three prospective. All the studies were assessed as high risk of bias. Meta-analysis on the HDRS scores from three retrospective studies showed that depressive patients with a suicide attempt during the on-going depressive episode had a significantly higher score on the HDRS compared to non-suicidal patients (mean difference 6.31 HDRS; 95% confidence interval 4.72 to 7.91; P<0.00001, I2=0). However, meta-analyses of the HDRS scores from three prospective studies and four studies reporting retrospectively lifetime suicide attempts showed no significant differences between patients with or without a suicide attempt or suicide.Conclusion:
A total score on the HDRS does not seem to be associated with past or future suicide attempts or suicides. There seems to be a need for other assessment tools to predict and explain risks of suicidality.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Br J Med Med Res
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS