Lack of expression of c-myc oncogene in peripheral blood mononuclear cells of patients with active rheumatoid arthritis.
Article
in English
| IMSEAR
| ID: sea-16283
ABSTRACT
We looked for the expression of c-myc oncogene, one of the genes that enhance apoptosis, in 11 patients with active rheumatoid arthritis (RA) along with five patients with osteoarthritis (OA) knee as disease controls and six healthy volunteers. A dot-blot assay using a probe specific for c-myc oncogene was performed on total RNA obtained from peripheral blood mononuclear cells. There was no expression in patients with active RA and healthy volunteers. One patient with OA expressed c-myc. Lack of expression of c-myc suggests that in active RA circulating lymphocytes are not in the replicative phase despite ongoing disease activity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Osteoarthritis
/
Arthritis, Rheumatoid
/
Aged
/
Female
/
Humans
/
Male
/
Leukocytes, Mononuclear
/
Case-Control Studies
/
Gene Expression Regulation
/
Genes, myc
Type of study:
Observational study
Language:
English
Year:
1996
Type:
Article
Similar
MEDLINE
...
LILACS
LIS