Comparative Effect of Type 1 and Type 2 Diabetes Mellitus on Vascular Responses of Rat Thoracic Aorta to Potassium Ion Channel Openers.
Br J Med Med Res
;
2013 Jul-Sep; 3(3): 748-759
Article
in English
| IMSEAR
| ID: sea-162883
ABSTRACT
Background:
Diabetes mellitus is associated with many cardiovascular dysfunction and impairment of potassium channel function.Aim:
We compared the vascular reactivity in aorta from streptozotocin-induced and Goto-Kakizaki (GK) diabetic rats to potassium channel openers.Methodology:
Diabetes mellitus (DM) was induced in Sprague Dawley rats by intraperitoneal injection of streptozotocin (STZ) at 65 mg/kg body weight. After four weeks of DM, vascular reactivity of the aortic rings from STZ-induced Sprague Dawley and age-matched GK and control rats to phenylephrine, acetylcholine, levcromakalim and naringenin was studied using standard organ bath procedure.Results:
The phenylephrine-induced contraction was significantly (P<0.05) increased in STZ-diabetic aortic rings [2.03 ±0.07 g] when compared with GK rats [1.47±0.14 g] and STZ-control [1.42±0.21 g]. Maximal relaxation and potency to acetylcholine, levcromakalim and (+/-)-naringenin were significantly (P<0.05) decreased in STZdiabetic aorta when compared with GK-diabetic and control groups.Conclusion:
The phenylephrine-induced contraction, endothelium-dependent relaxation, KATP - and (+/-)-naringenin-induced vasorelaxation are not altered in the early stages of Type 2 diabetes whereas there is exaggerated contractile response and a relaxant dysfunction involving the endothelium, KATP in Type 1 diabetes mellitus.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Journal:
Br J Med Med Res
Year:
2013
Type:
Article
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