Free Radical Scavenging Activities of Nyctanthes arbor-tristis. L on Adjuvant Induced Arthritis in Rats.
Article
in English
| IMSEAR
| ID: sea-163295
ABSTRACT
Aims:
The present study was undertaken to explore in vivo antioxidant potential of ethanol extracts of Nyctanthes arbor-tristis leaf and stem in adjuvant induced arthritic rats.Methodology:
Arthritis induced rats were administered with extract of Nyctanthes arbortristis leaf and stem. (150 mg/kg body Weight/rat/day for 30 days.Results:
A significant decrease in paw edema was observed following oral administration of the leaf and stem extracts. A significant (p<0.05) increase in the level of tissue TBARS, GPx and catalase was seen in arthritis induced rats (group II) and NAT treated rats (group III and group IV) showed a significant decrease in lipid peroxides, GPx and catalase level to near normalcy. The activity of total tissue SOD was found significantly (p<0.05) low in arthritis induced rats (group II) while a substantial increase in the activity to near normal level was noticed in NAT administered rats. The alterations in hematological and other biochemical parameters were restored to near normal levels after a treatment period of 30 days. The structural changes of the tissues shows the therapeutic ability of Nyctanthes arbor-tristis stem and leaf in experimental animals which were further evidenced by histological observations made on the hind limb tissue.Conclusion:
As Nyctanthes arbor-tristis is of natural origin, it is a safe and effective intervention for free radical mediated diseases.
Full text:
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Index:
IMSEAR (South-East Asia)
Main subject:
Arthritis, Experimental
/
Rats
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Superoxide Dismutase
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Plant Extracts
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Lipid Peroxidation
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Free Radical Scavengers
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Plant Leaves
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Oleaceae
/
Free Radicals
/
Animals
Language:
English
Year:
2013
Type:
Article
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