Hepatoprotective Effect of Momordica charantia Extract against CCl4 Induced Liver Damage in Rats.
Article
in English
| IMSEAR
| ID: sea-163370
ABSTRACT
Aim:
The study was aimed to evaluate Momordica charantia leaves extract for hepatoprotective effect against carbon tetrachloride (CCl4) induced hepatotoxicity in rats.Methodology:
A total of twenty five male rats were randomly divided into five groups of five rats each. The extract was administered orally for fifteen days at 200 and 400 mg/g body weight.Results:
The results obtained showed that, treatment with the extract significantly (P<0.05) restored liver weight to near normal. The result showed a significant (P<0.05) increase in Heamoglobin (Hb) and Packed Cell Volume (PCV) compared to toxin control group. Also treatment with the extract caused a significant (P<0.05) decrease in the activities of Alanine Transaminase (ALT), Aspartate Transaminase (AST), Alkaline Phosphatise (ALP) and the level of total bilirubin and a significant (P<0.05) increase in total protein level compared to control group. Similarly, the extract caused a significant (P<0.05) decrease in the level of reduced Glutathione (GSH) and Malondialdehyde (MDA) and a significant (P<0.05) elevation in the activities of Superoxide Dismutase (SOD) and Catalase (CAT) compared to toxin control group.Conclusion:
This study found that, administration of aqueous leaves extract of M. charantia ameliorated hepatotoxicity induced experimentally by CCl4.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Year:
2014
Type:
Article
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