Differential Spectrophotometric Method for Determination of Cefquinome Sulphate.

ABSTRACT

Differential first derivative (ΔD1) method is developed for the quantitative analysis of cefquinome sulphate (CS) in bulk and dosage form. The method is based on measuring the ΔD1 of CS in alkaline solutions against its neutral aqueous solutions as blanks. The proposed method is sensitive and highly specific, since the interference of the excipients or impurities is nullified. Beer’s law was obeyed over the concentration range 4-20 μg/mL with a limit of detection and limit of quantification 1.5 μg/mL and 4.8 μg/mL respectively.