Mineral status in thyroid disorders (hypo & hyper).

ABSTRACT

Thyroid hormones influences the metabolism of all the substrates including minerals. A patient with thyroid dysfunction may also manifests the symptoms that are consequents upon the altered minerals levels. The study shows that, low levels of Ca+ in hypothyroid cases, increased bone turnover in hyper thyroidism increases the Ca++ level decreased bone turnover. In hypothyroidism low tubular re absorption of Po4 - by affecting GFR, high clearance of Po4 -. In hyperthyroidism increased tubular re absorption of Po4 - affecting GFR, low clearance of Po4-. In hypothyroidism rapid blood flow will be leading to rapid clearance of Mg2+ & Zn+ from kidney. So over tubular excretion of Mg2+ & Zn+ will be low levels in plasma. In hyperthyroidism decreased blood flow will be leading to low clearance of Mg2+ & Zn+ from kidney. So low tubular excretion of Mg2+ & Zn+ will be high levels in plasma Materials & Methods The study was conducted over a period of six months. In this study 30 subjects hypo & 30 hyperthyroidism with euthyroidism were selected. Both males and females were included. Blood sample were collected for estimation of TSH, FT3,FT4, serum Ca, serum Po4 -, serum Mg2+ & serum Zn+. Results: In hypothyroid patients the serum levels of minerals Ca+, Zn+ , Mg2+ (p<0.001) were significantly decreased and PO4 (p<0.001) levels were significantly increased compared to controls. In hyperthyroid patients the serum levels of minerals Ca+, Zn+ , Mg2+ (p<0.001) were significantly increased and PO4 (p<0.001) levels were significantly decreased compared to controls. Conclusion: Mineral status is observed in all the patients Ca+ levels are low because high bone turnover prominent phosphorus levels positive influences on paratharmone and calcitonine, Zn+ & Mg2+ levels reflects the influences on GFR and decreased clearance of these minerals.